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Short Course DVDs


2014 DVDs

ADX_SC1_Thumbnail3Overcoming Challenges of Working with FFPE Samples
The course provide important insights for overcoming challenges of working with FFPE samples for cancer research such as detecting RNA and profiling miRNA expression. Next generation sequencing (NGS) utilizes FFPE samples for clinical retrospective studies. Successful interpretation of the samples depends on the quality of the starting material.

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ADX_SC3_Thumbnail3NGS Data Analysis – Determining Clinical Utility Of Genome Variants
Advances in NGS have provided unprecedented opportunities to mine genetic data from individuals to populations. The subsequent identification of genetic variants which may be implicated in disease is an important step in linking sequence data with disease and provides new approaches to improve human health. This course will explore the strategies of genomic data analysis and interpretation, an emergent discipline that seeks to deliver better answers from NGS data so that patients and their physicians can determine informed healthcare decisions.

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ADX_SC4_Thumbnail3Microfluidics for POC: Technologies, Applications and Products
The course will provide a broad overview of microfluidics as an enabling technology for point-of-care diagnostics. The course is constructed to provide a comprehensive overview of the field, starting with an introduction to microfluidics and its principles. Different manufacturing options will be discussed. Emphasis is put on the complete development process for commercial microfluidics-enabled POC-products, covering aspects of development strategies, application cases, markets as well as aspects of commercialization. The course covers the existing product landscape as well as exemplary disease cases with examples from molecular and immunodiagnostics. The course is suitable for scientists, technicians, engineers but also business developers who would like to develop a deeper understanding of microfluidics as a key technology for the development of new product in the POC markets.

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ADX_SC5_Thumbnail3Next Generation Sequencing as a Diagnostics Platform
Next generation sequencing (NGS) has revolutionized genomics and is now on the verge of being widely adopted for medical sequencing. Until recently, comprehensive genetic testing for genetically heterogeneous diseases was limited by the high cost of traditional (Sanger) sequencing technology. NGS technologies have now completely eliminated this limit such that virtually any gene with a published association to the disease of interest can be tested. Whole exome or whole genome sequencing (WES/WGS) is the ultimate genetic test and many success stories provide a taste of its power. However, while the cost of generating high-quality whole genome sequence data is rapidly dropping, analysis of the enormous number of variants detected is still too complex to implement WGS/WES as a first line genetic test. Targeted NGS-based gene panels are typically an order of magnitude smaller than WES/WGS based testing but follow the same principles. Screening large sets of genes is particularly useful when the clinical diagnosis is uncertain as it eliminates the need for costly and lengthy cascade testing that has dominated genetic testing in the past. Drawbacks are significantly increased numbers of detected variants, which poses novel challenges for post-analytic data analyses. The focus of this short course is on understanding the use of NGS in clinical diagnosis, practical implementation of NGS in clinical laboratories and analysis of large data sets by using bioinformatics tools to parse and interpret data in relation to the clinical phenotype. The concluding presentation is dedicated to quality and standardization of NGS assays.

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2011 DVDs

2011 SC1 DVD CoverMicro- and Nanofluidics in Diagnostics and Life Sciences: Technologies, Applications and Markets
This course is designed for scientists, managers, technicians and engineers who would like to acquire a comprehensive overview of the field of microfluidics. Starting with the underlying physical principles of miniaturization, the course includes an introduction into microfabrication technologies for microfluidic devices covering a wide range of existing materials (glass, silicon, polymers) and manufacturing technologies and describes the complete development cycle of a microfluidic device from the design to the ready-to-use device.

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2011 SC4 DVD CoverApplications of Detection Theory in Diagnostics
This course defines false positives, false negatives and dichotomous test as well as sensitivity, specificity, limit-of-detection, and response time. Attendees will understand and analyze a dose-response curve, construct and analyze a Receiver Operating Characteristic (ROC) curve from raw data, define Positive Predictive Value (PPV) and Negative Predictive Value (NPV), and interpret detector performance trade-offs using a ROC curve.

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2011 ADX SC8 DVD CoverThe Future of Point-of-Care Diagnostics
This short course looks at POCT markets and technologies from the point of view of senior executives making strategic choices about priorities and market directions. The discussion will focus on the changes in healthcare markets overall and the implications for POCT companies, especially as affected by molecular medicine. The multiple paths to market and potential barriers for POCT firms in the changing healthcare environment will be covered along with a range of potential strategies for success.

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2010 DVDs

2010 SC1 DVD CoverRoadmap for Accelerating Commercialization of Molecular DiagnosticsThis course is focused on the development of molecular diagnostics as they make their way from biomarker discovery and initial proof of clinical performance through to commercial launch and market development. The course emphasizes identification of critical hurdles that when addressed early, can materially accelerate progress. Vital areas that are covered include reimbursement strategies, regulatory path decisions, physician education and key opinion leader development.

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2010 SC3 DVD CoverFuture of Point-of-Care Platforms
This course looks at POCT markets and technologies from the point of view of senior executives making strategic choices about priorities and market directions.  The discussion focuses on the changes in healthcare markets overall and the implications for POCT companies, especially as affected by molecular medicine.  The multiple paths to market and potential barriers for POCT firms in the changing healthcare environment are also covered, along with a range of potential strategies for success.  This course is intended for decision-makers from POCT firms and investors, as well as diagnostic firms and scientists seeking a broader business view of point-of-care.

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2009 DVDs

Short Course 1Circulating Tumor Cells As Surrogate Endpoints In Clinical Trials
Recent trials using an FDA-cleared assay show that CTC number is a biomarker of prognosis and more predictive than posttherapy changes in PSA, raising the possibility that posttherapy changes in CTCs might represent an intermediate endpoint of treatment efficacy. The question of whether CTC counts are potential surrogates for survival is currently being addressed in the context of a phase 3 registration trial. Also under study are biologic profi ling of these tumors to explore the relationship between specific alterations in androgen receptor signaling and the response to novel agents targeting these alterations.

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 Short Course 2Reality Check On Companion Diagnostics
About the Course: 

  • Landscape of the companion diagnostic space today
  • Types of companion diagnostics tests
  • Clinical areas for companion diagnostic tests
  • Potential new companion diagnostic tests that will impact the market
  • Three fundamental steps in companion diagnostics
  • Impact on healthcare improvement and healthcare cost reduction
  • Where is the revenue coming from?
  • Who are the key players?
  • Where are the gaps?

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